The relevance of the research topic lies in the growing role of cross-border innovation clusters as an important tool for regional economic development and enhancing their competitiveness through integration into global economic and innovation networks. The aim of the study was to analyse the development of cross-border innovation clusters, identify their advantages and opportunities for internationalisation in the context of globalisation and European integration. To achieve this, conceptual analysis methods, case studies, and empirical research were employed, focusing on various cross-border clusters, particularly in Europe and beyond. The findings revealed that cross-border innovation clusters contribute to the reindustrialisation of regions, reduce dependency on large corporations, and create competitive advantages for small and medium-sized enterprises. Case study analysis, including examples such as Future Position X in Sweden and the Cascadia Innovation Corridor in North America, demonstrated the significant potential of cross-border initiatives to attract new technologies, resources, and international markets. Key factors influencing the effectiveness of such clusters were identified, including geopolitical and institutional proximity, scientific-technological interaction, as well as cultural and relational aspects of cross-regional collaboration. Additionally, a model for the internationalisation of regional clusters was developed, encompassing clear stages for the coordination and development of external relations, enabling the full realisation of the international potential of clusters and fostering their effective development. This study can be valuable for government bodies, regional administrations, cluster organisations, small and medium-sized enterprises, as well as academic institutions in the development of cross-border cooperation strategies, optimisation of internationalisation, and the enhancement of innovation development in border regions
cohesion policy; innovation policy; innovation systems; regional development; sustainable development
Received 20.08.2025, Revised 31.10.2025, Accepted 10.12.2025
Retrieved from Volume 18, No. 2, 2025
https://doi.org/10.56318/dg/2.2025.107
Pages 107-118
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